Information about Hifenac-MR Tablet

Hifenac-MR Tablet is a combination medication used to treat pain and muscle spasms associated with musculoskeletal conditions like back pain, neck pain, and sprains. It contains three active ingredients: Aceclofenac (an NSAID), Paracetamol (Acetaminophen), and Chlorzoxazone (a muscle relaxant). Together, they provide relief from pain, inflammation, and muscle stiffness or spasms.

Key Ingredients:

1. Aceclofenac (100 mg): A non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by blocking prostaglandin production.
2. Paracetamol (500 mg): An analgesic and antipyretic that helps reduce pain and fever by acting on the brain's pain receptors and lowering body temperature.
3. Chlorzoxazone (250 mg): A muscle relaxant that acts on the central nervous system to relieve muscle spasms and stiffness.

Uses:

1. Muscle Spasms: Helps in relieving muscle stiffness and spasms caused by conditions such as muscle strain, sprains, or sports injuries.
2. Back and Neck Pain: Effective in managing pain related to conditions like lumbago and cervical spondylosis.
3. Arthritis: Provides relief from pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis.
4. Post-Surgical Pain: Can be used to manage post-surgical or injury-related pain that involves muscle stiffness or spasms.

How It Works:

• Aceclofenac reduces inflammation and pain by inhibiting the enzymes (COX-1 and COX-2) that produce prostaglandins, which are responsible for causing inflammation and pain.
• Paracetamol enhances the pain-relieving effects of Aceclofenac and helps in reducing fever.
• Chlorzoxazone acts on the brain and spinal cord to reduce muscle stiffness, improve mobility, and alleviate pain from muscle spasms.

Dosage and Administration:

• Typical Dosage: One tablet taken 1 to 2 times daily, or as prescribed by a doctor.
• Take with food: This helps minimize the risk of stomach irritation, especially with NSAIDs like Aceclofenac.
• Duration: The duration of treatment depends on the condition being treated and the patient's response to the medication.

Side Effects:

Although Hifenac-MR is generally well-tolerated, it can cause some side effects, particularly with long-term use or in sensitive individuals:

• Common Side Effects:
  • Nausea or vomiting
  • Stomach discomfort or pain
  • Drowsiness or dizziness (due to Chlorzoxazone)
  • Heartburn or indigestion
  • Diarrhea or constipation
• Serious Side Effects (rare but require medical attention):
  • Gastrointestinal bleeding or ulcers (from NSAID use)
  • Allergic reactions like rashes, swelling, or breathing difficulties
  • Liver damage (especially with prolonged use of Paracetamol)
  • Severe drowsiness or muscle weakness

Precautions:

• Gastrointestinal Risks: Long-term use of NSAIDs like Aceclofenac can lead to stomach ulcers or gastrointestinal bleeding. It is advisable to take it with food and avoid prolonged use.
• Liver Health: Excessive use of Paracetamol can cause liver damage, especially if taken in doses higher than recommended.
• Drowsiness and Coordination: Chlorzoxazone can cause drowsiness and affect coordination, so avoid driving or operating heavy machinery while taking this medication.
• Pregnancy and Breastfeeding: Avoid using during pregnancy and breastfeeding unless specifically prescribed by a doctor.
• Alcohol: Limit alcohol intake while using this medication, as it can increase the risk of liver damage, particularly with Paracetamol.

Drug Interactions:

• Other NSAIDs: Avoid taking additional NSAIDs like ibuprofen or aspirin, as this can increase the risk of side effects.
• Blood Thinners: NSAIDs may increase the risk of bleeding if taken with anticoagulants like warfarin.
• Sedatives or Tranquilizers: Combining Chlorzoxazone with sedatives or alcohol can enhance drowsiness and dizziness.

Benefits:

• Relief from Pain and Muscle Spasms: Provides a comprehensive solution for pain associated with inflammation and muscle spasms.
• Improves Mobility: Relaxes stiff muscles, allowing for better movement and function.
• Multi-Symptom Control: Controls pain, fever, inflammation, and muscle stiffness with one tablet.

Storage:

• Store in a cool, dry place, away from direct sunlight.
• Keep out of reach of children.

Hifenac-MR Tablet is a highly effective medication for managing pain and muscle spasms associated with musculoskeletal disorders. However, it should be used under medical supervision, especially if it is needed for long-term treatment, to avoid potential side effects and complications related to NSAID and Paracetamol use.