Information about Nexpro RD 40 Capsule

Nexpro RD 40 Capsule SR is a combination medication that contains Esomeprazole (40 mg) and Domperidone (30 mg) in a sustained-release form. This combination is used to treat gastroesophageal reflux disease (GERD) and other acid-related stomach disorders that may also involve nausea and vomiting.

• Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production, relieving symptoms of acid reflux, heartburn, and aiding in the healing of the esophagus.
• Domperidone is a prokinetic agent that helps reduce nausea and improve gastric emptying, aiding in the movement of food through the stomach.

Uses:

Nexpro RD 40 Capsule SR is commonly prescribed for:

1. Gastroesophageal Reflux Disease (GERD) with symptoms like heartburn and acid regurgitation.
2. Erosive Esophagitis: For healing and prevention of relapse.
3. Dyspepsia (Indigestion) and Nausea/Vomiting associated with delayed gastric emptying.

Dosage and Administration:

• Typical Dosage: One capsule per day, taken at least 30 minutes before a meal, usually in the morning.
• Administration: Swallow the capsule whole with water. Do not crush or chew the capsule.

Side Effects:

Common side effects of Nexpro RD 40 include:

• Headache
• Nausea
• Dizziness
• Dry Mouth
• Abdominal Pain or Bloating
• Diarrhea or Constipation

Rarely, serious side effects such as severe allergic reactions, changes in heart rhythm, or signs of low magnesium levels may occur. Seek medical attention if these symptoms develop.

Precautions:

• Allergies: Avoid if allergic to Esomeprazole, Domperidone, or similar medications.
• Kidney or Liver Issues: Use with caution if you have significant kidney or liver impairment.
• Long-Term Use: Long-term use may lead to vitamin B12 deficiency, magnesium deficiency, or an increased risk of bone fractures.
• Pregnancy and Breastfeeding: Should be used only if prescribed by a doctor, as Domperidone may not be suitable for breastfeeding mothers.

Drug Interactions:

• Antifungal and Antiretroviral Drugs: Drugs like Ketoconazole or Atazanavir can be affected by Esomeprazole.
• Blood Thinners (e.g., Warfarin): May affect blood-clotting ability.
• Macrolide Antibiotics: Such as Erythromycin, may interact with Domperidone, affecting heart rhythm.
• Other PPIs or Antacids: Avoid concurrent use without consulting a doctor.

Storage:

• Store at room temperature, away from moisture and heat.
• Keep out of reach of children.

Summary:

Nexpro RD 40 Capsule SR combines Esomeprazole for acid reduction and Domperidone for nausea relief, making it useful for managing GERD with associated nausea. Follow the prescribed dosage and avoid long-term use unless directed by a doctor due to potential nutrient deficiencies and other risks.