Information about Grenil Tablet

The Grenil Tablet is a combination medication commonly prescribed for the treatment of migraines, severe headaches, and tension-type headaches. It is designed to alleviate the symptoms associated with these conditions, such as pain, throbbing, and sensitivity to light or sound.

1. Domperidone (20 mg):

• Class: Anti-emetic (prevents nausea and vomiting)
• Mechanism of Action: Domperidone works by blocking dopamine receptors in the gut and the brain, which helps in increasing the movements or contractions of the stomach and intestines. This action helps prevent nausea, vomiting, bloating, and discomfort caused by delayed gastric emptying.
• Uses:
  • Prevents nausea and vomiting
  • Relieves bloating and feelings of fullness
  • Helps with symptoms of gastroparesis (delayed stomach emptying)

2. Paracetamol (500 mg):

• Class: Analgesic and Antipyretic
• Mechanism of Action: Paracetamol works by inhibiting the production of chemicals in the brain that cause pain and fever. It is widely used for pain relief and to reduce fever.
• Uses:
  • Alleviates mild to moderate pain (e.g., headaches, toothaches, menstrual pain, muscle pain)
  • Reduces fever

Combination Use:

The combination of Domperidone and Paracetamol is particularly useful in treating migraine headaches, where both pain and nausea are common symptoms. Domperidone helps reduce the nausea or vomiting that might be caused by a migraine, while paracetamol helps alleviate the pain associated with it.

Indications:

• Migraine: To manage both headache pain and associated nausea or vomiting.
• Gastrointestinal pain with nausea: For conditions where pain is accompanied by digestive discomfort, bloating, or vomiting.

Dosage:

The dosage usually depends on the individual’s condition and is determined by a healthcare professional. Generally, it is taken one tablet or as directed by the doctor.

Side Effects:

• Domperidone:
  • Dry mouth
  • Drowsiness
  • Abdominal cramps
  • Dizziness
  • Rare: Irregular heartbeat (if used long-term or in high doses)
• Paracetamol:
  • Allergic reactions (rare)
  • Liver damage (if taken in excessive doses over time)

It’s important to consult a healthcare provider to ensure the combination is appropriate for your condition, especially if you have underlying health issues or are on other medications.